Optimal Length and Signal Amplification in Weakly Activated Signal Transduction Cascades
نویسندگان
چکیده
منابع مشابه
Optimal length and signal amplification in weakly activated signal transduction cascades
Weakly activated signaling cascades can be modeled as linear systems. The input-tooutput transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the characterization of the final outcome. The most efficient design of a cascade for generating sharp signals, is obtained by choosing all the off rates equa...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2004
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp048935f